The skin health and longevity company.

ACTIOGLOBAL delivers leading fermentation ingredients backed by science. We enable consumer brands to deliver proven, visible results in skin and hair health and longevity.

ACTIOGLOBAL delivers the best performing fermentation produced ingredients for consumer skin and hair brands that are committed to science backed efficacy, delivering the best skin & hair health and longevity for consumers.

World class team with proven track record, having commercialized 18 biomolecules that are the current market standard, developed and launched over 1000 consumer products with over 4.5 star rating.

World class team with proven track record.

18 fermentation produced molecules that set the market standard. Over 1000 consumer products launched. Join us on the mission to set the standard for skin and hair health and longevity.

Delivering the standard for Skin and Hair health and Longevity ingredients.

90%
Fewer impurities
The best fermentation squalane yet. The new standard in skin feel, collagen support, skin hydration and active delivery performance. Healthier for your skin, amplifies the performance of your formula and is the most sustainable squalane produced today.
40%
Smaller particle size
A formulator's best friend. Faster absorption, lighter feel, and a superior delivery system for actives.
1.5x
Better skin hydration
28-day clinical trial against previous generation fermentation squalane.

The formulator platform molecule for healthier skin and hair

The most shark like profile produced from fermented squalene. Lighter to the skin, faster absorption, and the most sustainable and reliable supply chain of any Squalane supply in the world.

99.5% purity
✓
The smoothest, cleanest squalane on the market. 99.5% purity your customers can feel in every application.
✓
No masking fragrances needed. Odorless, which simplifies your formulation and cuts costs.
✓
Upgrade from 1st generation fermentation, olive or animal sourced. For better performance, more secure supply, a price guarantee and the best sustainability.
✓
Boost efficacy of your actives. Superior carrier that amplifies delivery and performance in every formulation.

Catalisse™ Squalane is the performance standard.

Serums and face care
Skin Care
Serums & Face Oils
Sun care
Sun Care
SPF & Sun Protection
Color cosmetics
Color
Color Cosmetics
Hair care
Hair Care
Hair & Scalp
Innovation Pipeline

The next wave.

Beyond squalane: a pipeline of biomolecules built to set new standards in efficacy and sustainability.

Cutting Edge Innovation

Catalisse™ 2FL

Gentle HMO, retinol-grade efficacy

Stimulates collagen at levels comparable to retinol and restores the skin barrier 3x more effectively, without the irritation.

Skin Longevity

Catalisse™ Ectoine

Built for environmental stress

Stable under extreme heat and UV exposure. A natural extremolyte that protects skin cells from urban pollution and oxidative damage. The best way to protect skin hydration.

Next Wave

PGM (Performance Goat Milk)

Breakthrough bioavailability

We are unlocking the highest performing peptides and making goat milk as a skin care ingredient more available, delivering up to 2x increase in skin hydration. Fully odorless, enabling higher inclusion than any milk-derived active before.

Common Questions

Everything you need to know.

What makes Catalisse™ Squalane different from other squalane?

Catalisse™ Squalane is the 4th-generation fermentation squalane, 99.5% purity, >90% fewer impurities, and 40% smaller particle size than the previous fermentation generation. It delivers the closest physico-chemical profile to shark-derived squalane without any animal sourcing.

Will switching to Catalisse™ Squalane require reformulating my products?

In almost every case, no. The INCI name (Squalane) and regulatory status are identical to what you use today, and Catalisse™ Squalane's profile is the closest to shark-derived squalane of any commercial source. Formulators typically swap on a 1:1 basis with improved stability, sensorial, and claim implications. Our scientists support qualification through your stability protocols and provide formulation guides for skin care, sun care, hair, and color applications.

What are the recommended inclusion levels for specific formulations?

Observable skin benefits start at just 1–5% inclusion, but Catalisse™ Squalane's exceptional purity and neutral profile allow concentrations up to 90% in high-performance formulations such as facial oils, serums, and luxury body care. Beyond its standalone emollient effect, it acts as a penetration enhancer, boosting the delivery of other actives in your formula. This versatility lets you build a single hero ingredient across your entire portfolio, from lightweight daily moisturizers to intensive treatment products.

What sustainability and marketing claims can my brand make with Catalisse™ Squalane?

Catalisse™ Squalane is derived from plant-sugar fermentation with no animal origin. Our team provides claim-support documentation and formulation guidance under NDA so your sustainability and legal teams can vet claim language before any launch. Contact us for the full regulatory and sustainability dossier.

Who is behind ACTIOGLOBAL?

ACTIOGLOBAL is built by a team that has commercialized more than 18 biomolecules and brought 1,000+ beauty and wellness products to market with 4.5-star-or-higher ratings. Categories range from renewable lubricants and vitamin E to F&F ingredients, pharma squalene, and prior-generation squalane. Catalisse™ Squalane is the next chapter, not the first product.

Make your formula the consumer standard for skin health and longevity.

Discover the science and performance behind the NextGen Catalisse™ Squalane and our other standard setting fermentation ingredients today.

Next Gen
Catalisse™ Squalane

The best performing fermented squalane. Lighter on skin, faster absorbing, better carrier performance and no more heavy or oily feel on application. The most elegant feeling emollient delivered from the most sustainable and accessible supply chain. A squalane you can trust to be the power of your skin health and longevity products.

Purity
99.5%
Odor
None
Viscosity (~21°C)
~33.6 cP
Stability
Stable
Source
Sugar fermented squalene
INCI Name
Squalane
40%
Smaller particle size
vs. previous-gen fermentation squalane
50%
Better hydration
1.5x skin hydration in 28-day study
+10%
Collagen synthesis
in vitro vs. other squalane generations
20%
Lower viscosity
Lighter feel, easier emulsification
Odorless
Validated by sensory panel, every batch
Full transparency
Crystal-clear, colorless, no batch variation
Single-factory traceability
Fermentation to final product, one facility

The evolution of squalane:
from shark to NextGen Catalisse™ Squalane.

1st Generation
Shark Derived Squalane
An unsustainable source
  • Deep sea sharks endangered
  • Animal-derived, controversial
  • Banned in EU
  • Brand reputation risk
2nd Generation
Olive Derived Squalane
A volatile source
  • Supply & price volatility
  • Quality variability lot to lot
  • Lower purity (87–92%)
  • Irreversible cold haziness
3rd Generation
1st Gen Fermentation Squalane
Sugar derived
  • Stable supply & quality
  • High C30 purity
  • 92–94% overall purity
  • Higher viscosity than shark
4th Generation
ACTIOGLOBAL
NextGen Catalisse™ Squalane
  • 99.5% purity, best in category
  • Shark like viscosity & density
  • Odorless
  • Most sustainable and reliable supply chain and pricing
  • The industry standard source of Squalane

Comparing generations of Squalane

Property Shark Derived Olive Derived 1st Gen Fermentation NextGen Catalisse™ Squalane
Purity (%)>99~90.5~93.499.5
OdorSlight oilyOdorlessOdorlessOdorless
Density (g/mL)0.80840.81990.80930.8083
Viscosity (cP, 20.7°C)33.6341.7036.0733.57
Refractive Index1.45201.45511.45211.4502
StabilityStableStableStableStable

The standard for the next wave.

Baby and gentle skin care
Cutting Edge Innovation

Catalisse™ 2FL

A Human Milk Oligosaccharide and a genuinely gentle retinol alternative

2'FL is a Human Milk Oligosaccharide (HMO) naturally found in breast milk. Produced via eco friendly fermentation at >98% purity, it delivers retinol-grade results without the irritation.

A genuinely soothing option where aggressive actives are not appropriate. Water soluble and easy to incorporate into diverse cosmetic systems.

+117%
Filaggrin restoration with 2'FL vs. +39% with retinol
3x
Better skin barrier repair than retinol
>98%
Purity from eco friendly fermentation
  • ✓
    Stimulates collagen at levels comparable to retinol, significantly outperforming common peptide complexes and niacinamide
  • ✓
    Stimulates elastin at levels comparable to retinol, contributing to skin elasticity
  • ✓
    Significantly outperforms retinol in fibronectin stimulation
  • ✓
    Restores filaggrin, involucrin and keratins, the essential proteins behind skin barrier integrity
  • ✓
    Reduces pro-inflammatory cytokines IL-6, TNF-α and IL-1, helping to calm the inflammatory response
  • ✓
    Protects against urban pollution stress
Sun care and UV protection
Skin Longevity

Catalisse™ Ectoine

Our skin longevity molecule

A natural extremolyte that protects skin cells from environmental stressors. A promising alternative to Vitamin B3 (niacinamide) with superior stress resilience and UV protection. The best way to protect skin hydration.

  • ✓
    Survives extreme heat and environmental stress conditions
  • ✓
    Promising alternative to Vitamin B3 (niacinamide)
  • ✓
    Protects skin from urban dust and UV-induced damage
Hair care application
Hair & Lightweight Care

Catalisse™ Hemisqualane (under exploration)

A silicone substitute, naturally, in early exploration

Hemisqualane is an area our partner Cataya is actively investigating. If it moves into the portfolio, it will ship as part of the Catalisse™ range: a naturally derived lightweight emollient designed to replace silicones across hair and skin applications, without compromising the slip, finish or absorption profile that formulators expect.

  • ✓
    Superior hair penetration vs. conventional emollients
  • ✓
    Preserves hair color for longer wear
  • ✓
    Lightweight skin hydration with fast absorption
Hydration serum
Hydration Innovation

PGM (Performance Goat Milk)

An unexpected source for breakthrough hydration

We are unlocking the highest performing peptides and making goat milk as a skin care ingredient more available, delivering a genuine step forward in bioavailability for milk-derived actives. Odorless processing allows for higher inclusion rates than any milk-based ingredient available before, delivering over 40% improved skin cell turnover versus standard actives.

  • ✓
    Breakthrough bioavailability, unprecedented among milk proteins
  • ✓
    Up to 2x increase in skin hydration vs. conventional actives
  • ✓
    Fully odorless, enabling higher inclusion in formulations
  • ✓
    40%+ improved skin cell turnover rate

Ready to formulate? Work with the new standard.

Talk to our formulation team, or explore what's next in the pipeline.

Our difference starts with the science and continues with the factory. We have reinvented and set the new standard for Squalane production.

Simpler. Purer. One single factory.

Catalisse™ process delivers the most traceable, purity-focused fermentation squalane on the market, from the lowest carbon footprint and most reliable and predictable supply chain.

Renewable Feedstocks
Plant sugar
Fermentation
Biosynthesis
Squalene
Hydrogenation
Precision conversion
Catalisse™ Squalane
Squalane
Step 1

Controlled Fermentation

Squalene biosynthesis from renewable feedstocks in dedicated fermentation lines. Complete traceability within a single factory, from feedstock to finished molecule.

Step 2

Precision Hydrogenation

A streamlined downstream conversion of squalene to squalane. Fewer process steps in the same facility mean fewer impurity paths and more consistent results across every batch.

Step 3

Quantified Sustainability

Full lifecycle assessment tracked production: lower water usage, lower emissions and lower energy per kilogram than the previous generation of fermentation squalane.

Results that matter.

Backed by clinical results, real-world usage tests and preclinical human keratinocyte studies, with measurable benefits at the gene, cell and skin level.

Skin Hydration

1.5x
1.5x better skin hydration than the previous generation of fermentation squalane, confirmed in a 28-day clinical trial.
Clinical: 19 women aged 18–50, twice daily on inner forearm, weekly evaluation.

Wrinkle Reduction

51%
Visible reduction in wrinkle appearance at Day 28, documented through high-resolution matched digital photography.
Clinical: Reverse Photo Engineering analysis.

Hyaluronic Acid Boost

>5x
Over 5x higher expression of the HAS3 gene, the enzyme that synthesises hyaluronic acid inside the skin.
Preclinical: human keratinocyte model.

Skin Barrier Repair

+30%
~30% higher expression of the LOR and FLG genes, boosting Loricrin and Filaggrin production for firmer, more elastic skin. AQP3 (water-transport gene) also rises by ~30%.
Preclinical: human keratinocyte model.

Performance and better science backed efficacy across every category.

From body lotions and sun care to self-tanning and lipsticks, Catalisse™ Squalane raises the bar across every application.

Skin care serum
Skin Care
Serums & Face Oils
5–10% typical
Sun care
Sun Care
SPF & Sun Protection
3–5% typical
Makeup
Makeup
Color Cosmetics
3–10% typical
Hair care
Hair Care
Hair & Scalp
2–5% typical
Baby care
Baby Care
Baby & Sensitive Skin
5–10% typical
Serum face oil
Serums
Pure Carrier Serum
Up to 100%
Cleansers and face wash
Cleansers
Face Wash & Body Cleanse
3–8% typical
Body care cream
Body Care
Body Lotions & Creams
3–5% typical
In the Lab and On the Shelf

The ingredient brands trust to perform.

From luxury serums to mass-market sunscreens, Catalisse™ Squalane is the standard of choice for formulators who cannot compromise on purity or skin feel.

Premium serum and face cream formulated with Catalisse™

ACTIOGLOBAL is setting the standard for health, beauty and wellness ingredients that deliver the best in skin health and longevity performance.

We are reshaping how health, beauty and wellness brands access ingredients. Precision biochemistry is our tool. Proven performance is our promise.
John Melo, CEO & Founder
Our Team

Exceptional scientists,
proven leaders.

Together, our leadership has developed over 18 biomolecules, completed 6 successful exits and brought more than 1,000 beauty and wellness products to market.

John Melo

John Melo

CEO
  • Over 30 years of executing market innovation at global scale
  • Over 20 years leading biotech innovation for health, beauty and wellness markets
  • Developed 18+ commercial biomolecules
  • Led $2B+ in licenses and transactions
  • Helped create the Clean Beauty category
Dondeena Bradley

Dondeena Bradley, PhD

President
  • Senior leadership CPG health & wellness
  • Deep expertise across R&D & IP
  • Named a "40 Under 40" innovator by business press
Ana Carolina Galvão

Ana Carolina Galvão

Platform Development
  • 5+ years in biotechnology
  • Molecular research specialist
  • Product development excellence
  • Translates complex science into impactful innovations
Thiago Bizelli

Thiago Bizelli

Market Development
  • 6+ years in biotechnology
  • New biomolecule market entry specialist
  • International business development
  • MSc student in chemical engineering
Matt de Soto

Matt de Soto

Strategic Partnerships
  • 15+ years structuring deals across biotech, CPG and AI
  • Early stage customer acquisition specialist
  • Led global expansion for major brands
  • Converts tech platforms into revenue
João Fernandes

João Fernandes

Head of Ingredient Science
  • 10+ years driving Beauty & Personal Care innovation
  • Bioactive and functional ingredient innovation specialist
  • Drives discovery, formulation and validation programs
  • Translates advanced science into market-ready solutions

Operators that pioneered and set the standard for bio based ingredients in health, beauty and personal care markets.

Eighteen molecules. Touching over 300 million consumers daily. Enabling 1000's of brands globally.

The same team behind those programs is building Catalisse™ Squalane.

Growing with the right partners.

From the laboratory bench to the manufacturing floor and the distribution network, our partners set the industry standard for the ingredient value chain.

Cataya
Technology and Manufacturing Partner
View partner
Católica University of Porto - CBQF
R&D, Formulation and Testing Laboratory
View partner
Azelis | Vogler
Exclusive Distribution Partner, Brazil
View partner
Innovation and Manufacturing Partner

Cataya, the science behind Catalisse™ Squalane.

Cataya is our exclusive innovation and manufacturing partner: the team that creates the science and operates the fermentation and downstream lines where every batch of Catalisse™ products are produced.

About Cataya

Sustainable innovation, engineered by biology.

Cataya, named after Cathaya (the Chinese silver fir), was created to replace fossil-resource dependency with advanced and innovative fermentation technology. Headquartered in Shanghai, Cataya combines world-leading innovation capabilities with state-of-the-art, fully owned, internationally certified fermentation plants engineered for quality at scale.

For ACTIOGLOBAL, that means one factory, one team, and one continuous chain of custody, from plant-sugar feedstock to the finished Catalisse™ Squalane batch that reaches your lab.

Headquarters
Shanghai, China
Capabilities
Integrated R&D + fermentation manufacturing
Scale
>1,000 tons, with >2,000 tons under construction
Certifications
ISO, COSMOS (additional certifications on the way)
Why Cataya

Three reasons we chose them to make Catalisse™ Squalane.

Design-for-scale, from day one

Cataya's R&D and manufacturing are fully integrated in the same building. New strains and processes are engineered for scale-up from the first bench experiment, not retrofitted later. That's why the Catalisse™ product range can move from pilot to commercial volume without quality drift.

Single-factory traceability

Fermentation, hydrogenation, purification and packaging happen under one roof. One QC team, one batch record, one chain of custody: the simplest possible answer when a buyer's regulatory team asks "where did this come from?"

A regulatory track record we trust

Cataya has navigated FDA, EU and APAC regulatory frameworks across multiple molecules, and secured ISO and COSMOS certifications for its production lines. The same playbook supports Catalisse™ Squalane documentation for personal care launches, with additional certifications on the way.

Curious about the product? See the molecule Cataya manufactures for us.

R&D · Formulation · Testing

CBQF, the science behind every claim.

CBQF (Centre for Biotechnology and Fine Chemistry) is the biotech division inside Católica University of Porto. It's the academic R&D and testing partner behind the formulation work, application studies and validation protocols that sit underneath every Catalisse™ Squalane claim.

About the laboratory

An academic lab, built for industry-grade science.

Through UCP's scientific infrastructure, CBQF supports the discovery, development and validation of innovative ingredients and formulations for Beauty and Personal Care, at every step of the pipeline from bench to claim.

Testing capabilities

What we run at CBQF.

Skin biology & efficacy

  • Safety, hydration, anti-aging and anti-irritation assessment
  • Skin barrier, pollution and UV-radiation protection models
  • Contact dermatitis, atopic-prone and psoriasis-like skin models
  • Skin repair and re-epithelialization assays

Hair biology

  • Hair follicle growth, thickness and pigmentation studies
  • Hair tress analysis (combability, strength, shine and texture)

Formulation, safety & claims

  • Preservative activity and formulation protection assessment
  • Advanced cellular, molecular, analytical and imaging-based readouts for efficacy, safety and claims substantiation
R&D infrastructure

Instrumentation powering the work.

  • Confocal and fluorescence microscopy for high-resolution cellular imaging.
  • Cell and tissue culture laboratories for skin and hair biology work.
  • Cutometer and VISIOSCAN for objective skin-performance assessment.
  • Texture analyzer, viscosimeters and rheometer for formulation characterization.
  • FTIR and microDSC for structural and thermal analysis.
  • GC, HPLC and UHPLC-QTOF-MS/MS for analytical profiling.
  • Spectral flow cytometry and digital PCR for cellular and molecular analysis.
  • Homogenizers, spray dryers and freeze-dryer for prototype development.
The team

Researchers on the project.

The CBQF team dedicated to the ACTIOGLOBAL collaboration blends beauty-and-personal-care innovation with deep skin and hair biology expertise.

Team member portrait pending

João Fernandes

Beauty & Personal Care Innovation Lead
  • 10+ years driving Beauty & Personal Care innovation
  • Bioactive and functional ingredient innovation specialist
  • Drives discovery, formulation and validation programs
  • Translates advanced science into market-ready solutions
Team member portrait pending

Sofia Vieira

Skin & Hair Biology Research Scientist
  • Background in bioengineering and biomedical engineering
  • Specialist in biological evaluation of bioactive ingredients
  • Experienced with 3D skin models, explants and hair follicles
  • Supports skin and hair biology innovation
Exclusive Distribution Partner, Brazil

Azelis | Vogler, our gateway to Brazil.

Vogler is the largest specialty-ingredients distributor in Brazil and part of Azelis, the global distribution group. They are ACTIOGLOBAL's exclusive distribution partner for the Brazilian market, every kilogram of Catalisse™ Squalane sold in Brazil ships through them.

About Azelis | Vogler

A global network, with deep Brazilian roots.

Vogler is a long-established Brazilian distributor of specialty ingredients for personal care, food, pharma and nutraceuticals. Joining the Azelis group connected its on-the-ground sales, technical and logistics network to a global supplier base spanning more than 60 countries.

For ACTIOGLOBAL, that combination is unique: the closeness of a local partner that already supports Brazilian formulators day-to-day, backed by the operational rigor of a global distribution group.

Headquarters
São Bernardo do Campo, SP
Northeast branch
Cabo de Santo Agostinho, PE
Group
Part of Azelis (global specialty distribution)
Certification
Vogler Systems, FSSC 22000 certified
Segments served

A single partner across every relevant category.

Personal Care

The home of Catalisse™ Squalane in Brazil: skin care, sun care, color cosmetics, hair care and body care formulators across the country.

Food & Nutrition

Long-standing leadership in food-grade ingredient distribution, including the FSSC 22000-certified Vogler Systems unit for technological solutions.

Pharma & Nutraceuticals

Regulated-market expertise across pharma, animal nutrition and sports nutrition, the channel we tap into for future ACTIOGLOBAL pipeline molecules.

Based in Brazil? Order Catalisse™ Squalane through Vogler.

For pricing, data and technical support in Brazil, the fastest path is through our distribution partner.

Visit vogler.com.br
Contact Us

Let's raise the bar together.

Whether you are a beauty brand formulator, a distribution partner or an early stage collaborator exploring our pipeline, we would love to hear from you.

Get in touch with our team

We typically respond within one business day. Technical data is shared under NDA when needed.

Get in touch directly

TB

Thiago Bizelli

Market Development
tbizelli@actioglobal.co
AG

Ana Carolina Galvão

Platform Development
galvao@actioglobal.co

What happens after you reach out?

1
We respond within 1 business day
A brief conversation to understand what you are looking for and how we can help.
2
Technical data & specs
Full clinical data, specs and formulation guides, shared under NDA when appropriate.
3
Formulation support
Our scientists stay with you from early bench work through to commercial launch.
Product Innovation Clinic

Put your next product through the innovation clinic.

During our clinic we will review the technical differences amongst the different squalane sources and provide a detailed analysis of what you can expect when using NextGen Catalisse™ Squalane or Catalisse™ 2FL in your formulation. This is a session led by one of our ingredient scientists to support your transition to better skin health and longevity product efficacy.

Request your clinic session

Tell us where to reach you. We review every request personally, so we only accept commercial email addresses.

What to expect

1
Screening within 24 hours
We review your request and reply within one business day to confirm fit and understand your goals.
2
A 30 minute session within 10 days
We schedule a focused 30 minute session with one of our ingredient and formulation scientists.
3
Clear next steps
You leave with concrete recommendations on gaps, feasibility and how to strengthen the product before scale up.